First, look at the two images.

The above image has a sharp font, Window's DPI set at 100%.

and this image is less sharp, Window's DPI set at 200%.
The flag #PB_Font_HighQuality in LoadFont() has no effect. (I wonder when we see any difference, since the quality is always the same, with or without this flag).
Perhaps it is something that PureBasic still need to correct for DPI awareness?